Decoding Cells:

A Cell Analysis Blog

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Harnessing the Power of the Immune System: Optimizing T Cell Killing Cancer Immunotherapy

May 22nd, 2019

Immunotherapy has emerged as a real game-changer in cancer therapeutics. After decades of research, there is now hope of boosting an individual’s own immune system to fight cancer by tapping into T cell-based therapies. One group of patients particularly benefiting from these new approaches are those with malignancies previously considered ‘difficult to treat’. Novel immune therapies include chimeric antigen receptor T cell (CAR-T) therapy and TCR-based adoptive T cell (TCR-T) therapy.

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Benefits of live-cell analysis for stem cell workflows

May 1st, 2019

Censo Biotechnologies is a leader in the development of induced Pluripotent Stem Cells (iPSCs) and their differentiation into specific cell types for use in drug discovery. Censo provides a full spectrum of services to pharmaceutical companies, such as iPSC generation, genome editing, optimization of differentiation, and assay industrialization.

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Recent trends in immuno-oncology research and therapy

April 30th, 2019

Some of the challenges in understanding immuno-oncology (I-O) research and treating cancer using I-O therapies arise from the complex interactions between a patient’s immune system and the tumor’s biology. After all, tumors are populations of cells, and populations are subject to evolutionary forces.

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White Paper: Live-cell Analysis for Neuroscientists

January 18th, 2019

In this article, we discuss several neurobiology-specific applications using live-cell analysis to assess such processes as basic iPSC-derived neuronal cell health, neurite dynamics, neuronal activity, and microglial phagocytosis and chemotaxis. These assays are noninvasive, nonperturbing, and cell sparing, thus providing a valuable complement to other end-point techniques.

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White Paper: Unraveling the Complexities of Neurological Disease and Injury with Real-time Live-cell Analysis

January 18th, 2019

In this whitepaper learn, how real-time live-cell analysis could be a valuable tool for use in neurological disease model development, the study of disease pathology, neuroinflammation, nervous system injury, and drug discovery.

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Trapping Microbes: Live-Cell Visualization of NETosis

January 14th, 2019

As first responders against pathogens, the neutrophils migrate from the blood to the infected site to engulf and kill bacteria. In 2004, it was discovered that neutrophils can also kill microbes extracellularly by releasing neutrophil extracellular traps (NETs).

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In Bad Company: How Dysfunctional Glia Affect Neighboring Neurons

November 14th, 2018

RNA toxicity due to repeat-containing RNA can cause neurological diseases through gain of function. One such RNA repeat disorder is myotonic dystrophy type 1 (DM1), affecting intellectual abilities and central nervous system impairment, among other symptoms. Although a well-known RNA toxicity disorder, the molecular and cellular pathways affected in DM1 brain remain largely unknown.

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Expert view: New developments in real‑time live‑cell analysis

September 5th, 2018 | Del Trezise, Senior Director at Sartorius

Live-cell analysis is now a well-established method that is part of the everyday cell biologist’s armoury for understanding cell biology. For over a decade, the functionality, throughput, and ease of use offered by real-time live-cell analysis has provided a platform for accurate and reproducible cell biology analysis in multiple biomedical research areas, including oncology, immuno-oncology, immunology and now neuroscience.

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Capture Protein Expression Changes Over Time in Living Cells

August 23rd, 2018

Immunocytochemistry (ICC) as a basic cell imaging technique has been engrained into every cell biologist’s repertoire. Fluorescently labeled antibodies added onto fixed cells help visualize protein expression in the cells. While traditional ICC yields information on protein localization i.e. where the protein of interest is expressed, a big caveat remains – it is unable to capture protein expression changes over time, the ‘when’ of cellular dynamics.

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The Immune System Reacts to Neurological Stress: Catching Killer T Cells Live in Action

April 6th, 2018

Reactive oxygen species (ROS) have long suffered a bad rap. An overdose of ROS is detrimental and causes a state of oxidative stress. But eliminating them isn’t the answer either as our bodies need ROS for basic survival. Moreover, ROS are essential to immune system function, and act to combat perceived threats to the body. However, a lot is unknown about the role of ROS signaling in immune responses, especially in a diseased state.

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