Video: The Brave New World of Immuno-Oncology
To develop and validate next generation immuno-oncology therapies researchers have a need to study the basic functions of tumor and immune cells in isolation and together. In vitro tumor cell proliferation, migration and invasion assays enable the assessment of cancer cell growth and metastatic potential. Immune cell activation and chemotactic migration assays are used to study how the body mobilizes its forces against foreign cancer cells. Models of immune cell killing and tumor cell clearance are used to characterize therapeutic activity.
Common assays for measuring these key functions are often end point, require cell lifting or measure indirect readouts meaning valuable data may be overlooked or compromised. They provide little or no information around the time course of events and are unable to reveal the dynamic interactions between cells.
The IncuCyte® Live-Cell Analysis System enables real-time, automated and direct measurements of the dynamic interactions between immune and cancer cells. The system fits seamlessly in to existing research workflows. Non-invasive measurements mean that cells or supernatants can be used for downstream assays or further complementary analyses (e.g. flow cytometry, biochemical analysis).
- These real-time, live-cell assays provide deeper biological insight into the full time course of events.
- Direct, image-based analyses offer valuable morphological information and ensure every measurement can be validated with images and movies.
- Fully automated image capture and analysis enhance workflow productivity