Cell Analysis Blog

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Cell Analysis Blog

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Software: Identify where the cells within your gate fall in the all events plot, using the "Back Gate"

December 13th, 2019

Back gating helps to identify where the cells within your gate fall, within the all events plot. Back gating helps confirm your gating strategy, particularly for forward scatter vs. side scatter.

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Uncovering the Secrets of Cellular Motility: The Impact of Actin Nt-Acetylation on the Cytoskeleton

December 9th, 2019

Cellular motility in animals is a dynamic process, dependent on the interactions of microfilaments (e.g. actin and myosin), intermediate filaments (e.g. keratin), and microtubules. Working together in concert, these cytoskeletal structures engage in cellular activities such as cellular migration, transportation of vesicles, and gene transcription to name a few. In particular, the actin protein is a busy player; shuffling states between polymerization at the leading edge of cells to help pull them forward, and depolymerization at the trailing edge, pushing them from behind.

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Live Cell Analysis for Neuroscience Research

December 5th, 2019

Susana Alcantara, Senior R&D Scientist and Neuroscience Program Leader, BioAnalytics, of Sartorius, chatted with Brandy Sargent of Cell Culture Dish about how real-time live cell analysis is enabling neuroscience research.

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CRISPR: uncovering clues with off-target therapeutic implications

November 7th, 2019

Exploiting bacterial defense mechanisms has led to the development of CRISPR technology for gene editing and identification. CRISPR has become a popular research tool in the fight against cancer, neurological disease, heart failure, and other rare conditions in desperate need of new therapeutic options. With new technology, however, comes new questions: one being how to best to monitor possible off-target effects that might arise from experimental manipulations and determine the factors that contribute? This is not an easy question to answer.

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Software: Automatically identify populations of interest with 'Smart Gate'

October 29th, 2019

Gates used during flow cytometry data analysis aren’t 100% accurate even with a template. The integrated ForeCyt® Software on the iQue3 advanced flow cytometry platform addresses this issue with “Smart gate”, which automatically identifies the population of interest by centering itself on the closest dense area on the graph.

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Real-time visualization and quantification of neutrophil activation and function using Live-Cell Analysis

October 18th, 2019

Here’s a chance to see a poster presentation come to life. The poster was originally displayed at the annual meeting of the American Association of Immunologists (AAI) 2019.

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The Trouble with ELISA

September 25th, 2019

In this article, we discuss some of the current challenges of the ELISA assay, some alternatives for immunoassay (particularly flow cytometry), and some tools and technologies that can address the limitations of ELISA and other immunoassays.

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How Scientists are Working to Fight the Deadliest Form of Cancer with Oncolytic Viruses

September 12th, 2019

Dr. Pierre Cordelier describes how some exciting pre-clinical data suggests oncolytic viruses could tackle pancreatic cancer

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Antibody Screening Tools, Improving Workflows

August 14th, 2019

Helping researchers identify, characterize and investigate new antibody candidates, fuels the growing demand for therapeutic antibodies.

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Immune Cell Killing, Multi-Spheroids

August 6th, 2019

It is captivating to observe how Herceptin alone, or peripheral blood mononuclear cells (PBMCs) alone, have little or no effect on multi-spheroid size or viability (fluorescence intensity) of SKOV-3 multi-spheroid proliferations.

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