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CRISPR: uncovering clues with off-target therapeutic implications
November 7th, 2019
Exploiting bacterial defense mechanisms has led to the development of CRISPR technology for gene editing and identification. CRISPR has become a popular research tool in the fight against cancer, neurological disease, heart failure, and other rare conditions in desperate need of new therapeutic options. With new technology, however, comes new questions: one being how to best to monitor possible off-target effects that might arise from experimental manipulations and determine the factors that contribute? This is not an easy question to answer.
View articleInvestigating New Cancer Therapy Candidates with Live-Cell Imaging
July 11th, 2019
Professor Lawrence Kwong gives an overview of his research into cancer and the mechanisms that he and his research team are looking to target with novel therapy candidates.
View articleHarnessing the Power of the Immune System: Optimizing T Cell Killing Cancer Immunotherapy
May 22nd, 2019
Immunotherapy has emerged as a real game-changer in cancer therapeutics. After decades of research, there is now hope of boosting an individual’s own immune system to fight cancer by tapping into T cell-based therapies. One group of patients particularly benefiting from these new approaches are those with malignancies previously considered ‘difficult to treat’. Novel immune therapies include chimeric antigen receptor T cell (CAR-T) therapy and TCR-based adoptive T cell (TCR-T) therapy.
View articleBenefits of live-cell analysis for stem cell workflows
May 1st, 2019
Censo Biotechnologies is a leader in the development of induced Pluripotent Stem Cells (iPSCs) and their differentiation into specific cell types for use in drug discovery. Censo provides a full spectrum of services to pharmaceutical companies, such as iPSC generation, genome editing, optimization of differentiation, and assay industrialization.
View articleRecent trends in immuno-oncology research and therapy
April 30th, 2019
Some of the challenges in understanding immuno-oncology (I-O) research and treating cancer using I-O therapies arise from the complex interactions between a patient’s immune system and the tumor’s biology. After all, tumors are populations of cells, and populations are subject to evolutionary forces.
View articleWhite Paper: Unraveling the Complexities of Neurological Disease and Injury with Real-time Live-cell Analysis
January 18th, 2019
In this whitepaper learn, how real-time live-cell analysis could be a valuable tool for use in neurological disease model development, the study of disease pathology, neuroinflammation, nervous system injury, and drug discovery.
View articleWhite Paper: Live-cell Analysis for Neuroscientists
January 18th, 2019
In this article, we discuss several neurobiology-specific applications using live-cell analysis to assess such processes as basic iPSC-derived neuronal cell health, neurite dynamics, neuronal activity, and microglial phagocytosis and chemotaxis. These assays are noninvasive, nonperturbing, and cell sparing, thus providing a valuable complement to other end-point techniques.
View articleTrapping Microbes: Live-Cell Visualization of NETosis
January 14th, 2019
As first responders against pathogens, the neutrophils migrate from the blood to the infected site to engulf and kill bacteria. In 2004, it was discovered that neutrophils can also kill microbes extracellularly by releasing neutrophil extracellular traps (NETs).
View articleIn Bad Company: How Dysfunctional Glia Affect Neighboring Neurons
November 14th, 2018
RNA toxicity due to repeat-containing RNA can cause neurological diseases through gain of function. One such RNA repeat disorder is myotonic dystrophy type 1 (DM1), affecting intellectual abilities and central nervous system impairment, among other symptoms. Although a well-known RNA toxicity disorder, the molecular and cellular pathways affected in DM1 brain remain largely unknown.
View articleExpert view: New developments in real‑time live‑cell analysis
September 5th, 2018 | Del Trezise, Senior Director at Sartorius
Live-cell analysis is now a well-established method that is part of the everyday cell biologist’s armoury for understanding cell biology. For over a decade, the functionality, throughput, and ease of use offered by real-time live-cell analysis has provided a platform for accurate and reproducible cell biology analysis in multiple biomedical research areas, including oncology, immuno-oncology, immunology and now neuroscience.
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