IncuCyte® Research Areas

Neuroscience Literature and Resources

Neuroscience publications

References for Neurological Disease Model Development

Akhtar AA, et al. Inducible expression of GDNF in transplanted iPSC-derived neural progenitor cells. Stem Cell Reports, 2018, Jun 5; 10(6):1696-1704.

Bamba Y, et al. Visualization of migration of human cortical neurons generated from induced pluripotent stem cells. J Neurosci Methods, 2017, Sep 1; 289:57-63.

Bohlen CJ, et al. Diverse requirements for microglial survival, specification, and function revealed by defined-medium cultures. Neuron, 2017, May 17; 94(4):759-773, e8.  

Bressan RB, et al. Efficient CRISPR/Cas9-assisted gene targeting enables rapid and precise genetic manipulation of mammalian neural stem cells. Development, 2017, Feb 15; 144(4):635-648.

Cavaliere F, et al. In vitro α-synuclein neurotoxicity and spreading among neurons and astrocytes using Lewy body extracts from Parkinson disease brains. Neurobiol Dis., 2017, Jul; 103:101-112.

He Y., et al. RNA sequencing analysis reveals quiescent microglia isolation methods from postnatal mouse brains and limitations of BV2 cells. J Neuroinflammation, 2018, May 22; 15(1):153.

Ihry RJ, et al. p53 inhibits CRISPR-Cas9 engineering in human pluripotent stem cells. Nat Med., 2018, Jul; 24(7):939-946.

Kobayashi W, et al. Culture systems of dissociated mouse and human pluripotent stem cell-derived retinal ganglion cells purified by two-step immunopanningInvest Ophthalmol Vis Sci., 2018, Feb 1; 59(2):776-787.

Nguyen LS, et al.  Role of miR-146a in neural stem cell differentiation and neural lineage determination: relevance for neurodevelopmental disorders. Mol Autism, 2018, Jun 19; 9:38.

Ogura T, Sakaguchi H, Miyamoto S,  and Takahashi J. Three-dimensional induction of dorsal, intermediate and ventral spinal cord tissues from human pluripotent stem cells. Development, 2018, Jul 30; 145(16).

Robinson M, Douglas S, and Michelle Willerth S. Mechanically stable fibrin scaffolds promote viability and induce neurite outgrowth in neural aggregates derived from human induced pluripotent stem cells. Sci Rep., 2017, Jul 24; 7(1):6250.

Sloan SA, et al. Human astrocyte maturation captured in 3D cerebral cortical spheroids derived from pluripotent stem cells. Neuron, 2017, Aug 16; 95(4):779-790, e6.

Takayama Y, et al. Brief exposure to small molecules allows induction of mouse embryonic fibroblasts into neural crest-like precursors. FEBS Lett., 2017, Feb; 591(4):590-602.

Usenovic, M. et al. Internalized tau oligomers cause neurodegeneration by inducing accumulation of pathogenic tau in human neurons derived from induced pluripotent stem cells. J. Neurosci., 2015, 35(42):14234–14250.

References for Neurological Disease Mechanisms and Pathology

References for Neuroinflammation and Neuroprotection

Alawieyah Syed Mortadza S, Sim JA, Neubrand VE, and Jiang L. A critical role of TRPM2 channel in Aβ42 -induced microglial activation and generation of tumor necrosis factor-α. Glia, 2018, Mar; 66(3):562-575.

Cheng Q, et al. TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function. J Biol Chem., 2018, Aug 10; 293(32):12620-12633.

Daniels BP, et al. RIPK3 restricts viral pathogenesis via cell death-independent neuroinflammation. Cell, 2017, Apr 6; 169(2):301-313, e11.

Liddelow SA, et al. Neurotoxic reactive astrocytes are induced by activated microglia. Nature, 2017, Jan 26; 541(7638):481-487.

Manresa-Arraut A, et al. RhoA drives T-Cell activation and encephalitogenic potential in an animal model of multiple sclerosis. Front Immunol., 2018, May 31; 9:1235.

Manresa-Arraut A, et al.  RhoA-ROCK pathway is important for T-Cell migration in a mouse stroke model.  Journal of Translational Neurosciences, 2017, Dec; (2) No. 1:3 pg. 1-9.

Peng T, et al. Keratinocytes produce IL-17c to protect peripheral nervous systems during human HSV-2 reactivation. J Exp Med., 2017, Aug 7; 214(8):2315-2329.

Zorina Y, et al. Human IgM antibody rHIgM22 promotes phagocytic clearance of myelin debris by microglia. Sci Rep., 2018, Jun 20; 8(1):9392.

References for Nervous System Injury

References for Identification of Drug Targets and Therapeutic Development

Collier TJ, et al. Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form. Neurobiol Dis., 2017, Oct; 106:191-204.

Jin M, et al. An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease. Nat Commun., 2018, Jul 11; 9(1):2676.

Li WY, et al. AAV-KLF7 promotes descending propriospinal neuron axonal plasticity after spinal cord injury. Neural Plast., 2017, 2017:1621629.

Lu B. et al. Identification of NUB1 as a suppressor of mutant Huntington toxicity via enhanced protein clearanceNat Neurosci., 2013, May; 16(5):562-70.

Oiknine-Djian E, et al. The artemisinin derivative artemisone is a potent inhibitor of human cytomegalovirus replication. Antimicrob Agents Chemother., 2018, Jun 26; 62(7).

Paik S, Somvanshi RK, and Kumar U. Somatostatin maintains permeability and integrity of blood-brain barrier in β-Amyloid induced toxicity. Mol Neurobiol., 2018, Apr 26.

Piñero G, et al. Lithium reversibly inhibits Schwann cell proliferation and differentiation without inducing myelin loss. Mol Neurobiol., 2017, Dec; 54(10):8287-8307.

Rana P, et al. Utilization of iPSC-derived human neurons for high-throughput drug-induced peripheral neuropathy screening. Toxicol In Vitro, 2017, Dec; 45(Pt 1):111-118.

Sellgren CM, et al. Patient-specific models of microglia-mediated engulfment of synapses and neural progenitors. Mol Psychiatry. 2017 Feb; 22(2):170-177.

Yu M, et al. Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models. Cell Res.,2017, Dec; 27(12): 1441–1465.

Zhang Y, et al. Rapid single-step induction of functional neurons from human pluripotent stem cells.  Neuron, 2013, 78(5): 785–798.

Zhou Z, et al. Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes. J Neuroinflammation., 2017; 14: 75.

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