The CD47 ‘don’t eat me’ signal is a critical regulator of cancer, neuronal pruning, inflammation, and other pathophysiological processes and, therefore, an attractive therapeutic target.
In cancer, CD47 overexpression is used by tumor cells for cancer immune evasion. Consequently, methods to block CD47 signaling are being researched as potential cancer immunotherapies.
However, developing effective immunotherapies requires understanding the complex dynamics of CD47 signaling and regulation of phagocytosis.
Download this Infographic for an overview of the dynamics of CD47 signaling in the regulation of cancer, inflammation and neuronal pruning and methods to target this pathway for potential immunotherapies.