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CRISPR: uncovering clues with off-target therapeutic implications

November 7th, 2019

Exploiting bacterial defense mechanisms has led to the development of CRISPR technology for gene editing and identification. CRISPR has become a popular research tool in the fight against cancer, neurological disease, heart failure, and other rare conditions in desperate need of new therapeutic options. With new technology, however, comes new questions: one being how to best to monitor possible off-target effects that might arise from experimental manipulations and determine the factors that contribute? This is not an easy question to answer.

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Software: Automatically identify populations of interest with 'Smart Gate'

October 29th, 2019

Gates used during flow cytometry data analysis aren’t 100% accurate even with a template. The integrated ForeCyt® Software on the iQue3 advanced flow cytometry platform addresses this issue with “Smart gate”, which automatically identifies the population of interest by centering itself on the closest dense area on the graph.

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Real-time visualization and quantification of neutrophil activation and function using Live-Cell Analysis

October 18th, 2019

Here’s a chance to see a poster presentation come to life. The poster was originally displayed at the annual meeting of the American Association of Immunologists (AAI) 2019.

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The Trouble with ELISA

September 25th, 2019

In this article, we discuss some of the current challenges of the ELISA assay, some alternatives for immunoassay (particularly flow cytometry), and some tools and technologies that can address the limitations of ELISA and other immunoassays.

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How Scientists are Working to Fight the Deadliest Form of Cancer with Oncolytic Viruses

September 12th, 2019

Dr. Pierre Cordelier describes how some exciting pre-clinical data suggests oncolytic viruses could tackle pancreatic cancer

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Antibody Screening Tools, Improving Workflows

August 14th, 2019

Helping researchers identify, characterize and investigate new antibody candidates, fuels the growing demand for therapeutic antibodies.

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Immune Cell Killing, Multi-Spheroids

August 6th, 2019

It is captivating to observe how Herceptin alone, or peripheral blood mononuclear cells (PBMCs) alone, have little or no effect on multi-spheroid size or viability (fluorescence intensity) of SKOV-3 multi-spheroid proliferations.

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Immune Cell Killing, Single Spheroid

July 16th, 2019

Watch how Herceptin alone, or peripheral blood mononuclear cells (PBMCs) alone, have no significant effect on the growth of a SKOV-3 ovarian tumor spheroid.

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Investigating New Cancer Therapy Candidates with Live-Cell Imaging

July 11th, 2019

Professor Lawrence Kwong gives an overview of his research into cancer and the mechanisms that he and his research team are looking to target with novel therapy candidates.

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Harnessing the Power of the Immune System: Optimizing T Cell Killing Cancer Immunotherapy

May 22nd, 2019

Immunotherapy has emerged as a real game-changer in cancer therapeutics. After decades of research, there is now hope of boosting an individual’s own immune system to fight cancer by tapping into T cell-based therapies. One group of patients particularly benefiting from these new approaches are those with malignancies previously considered ‘difficult to treat’. Novel immune therapies include chimeric antigen receptor T cell (CAR-T) therapy and TCR-based adoptive T cell (TCR-T) therapy.

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