Monoclonal antibodies (mAb) and antibody-drug conjugates (ADCs) are widely used biological therapeutics. A key property of these biologics is the extent and rate of internalization into different cells, which governs their efficacy, safety and pharmaco-dynamic profile. As a result, quantifying and comparing the rate of Ab internalization of drug candidates is critical in the biopharmaceutical selection and optimization process.
Nicola is currently a Principal Scientist within our UK Biology R&D team based at our European laboratories. A highly experienced cellular pharmacologist with 22 years’ experience, she has worked within the Pharmaceutical and Biotech industry where she has gained a broad range of skills supporting early drug discovery programmes. Applying her pharmacological expertise, Nicola supported compound profiling in an industrial screening department (GSK). Nicola joined Essen in 2012 and is utilising her expertise to develop novel applications and biological reagents for drug discovery with a focus on building assays for quantitative live cell analysis using the IncuCyte system.