Immune-cell recognition and the targeting of harmful cells, such as cancer, is a critical component of our human host defense mechanism. Cytotoxic cell killing, also known as “T cell killing” is a mechanism of our immune response.
The IncuCyte™ Immune Cell Killing Assay is an integrated solution for real-time visualization and automated analysis of T cell killing– all within your tissue culture incubator.
During an immune response, specific cells of the immune system, such as T lymphocytes, change dynamically in order to fight infection or disease. These changes are fundamental to regulating the effect and extent of the immune response.
The IncuCyte™ immune cell clustering & proliferation assays allow visualization and quantification of immune cell interactions and proliferation in real time. Explore the mechanisms of proliferation, regulation and clustering within your incubator and without the need to lift or label your cells.
Chemotaxis is the directional movement of cells in response to a chemical stimulus, and is an essential component of immune responses, tumor metastasis, wound healing and blood vessel formation.
An integrated solution for real-time visualization and automated analysis of chemotactic cell migration for label-free or fluorescently labeled cells in a 96-well format – all within your tissue culture incubator.
This upgraded version for the IncuCyte ZOOM® Live-Cell Imaging system provides key enhancements for performing assays.
Upgrade is free for units currently under warranty.
The number of IncuCyte™ references has now surpassed 500! Below are three highlights from July, 2015.
Inhibition of endogenous hydrogen sulfide production in clear-cell renal cell carcinoma cell lines and xenografts restricts their growth, survival and angiogenic potential Sonke E,Verrydt M,Postenka CO,Pardhan S,Willie CJ,Mazzola CR,Hammers MD,Pluth MD,Lobb I,Power NE,Chambers AF,Leong HS,Sener A,
Nitric Oxide, 49:26-39, 2015
Real-time monitoring of the hypoxic marker, hydrogen sulfide, using IncuCyte ZOOM® reveals novel therapeutic opportunities in the fight against renal cell carcinoma.
Targeting the podocyte to treat glomerular kidney disease
Lal MA,Young KW,Andag U,
Drug Discov. Today, pii: S1359-6446(15)00233-0, 2015
Researchers at AstraZeneca and Evotec use IncuCyte™ to functionally validate and assess the potency of screening hits in an ex vivo model of diabetic nephropathy revealing novel opportunities for kidney-specific therapeutics.
The HDAC Inhibitors Scriptaid and LBH589 Combined with the Oncolytic Virus Delta24-RGD Exert Enhanced Anti-Tumor Efficacy in Patient-Derived Glioblastoma Cells Pont LMEB,Kleijn A,Kloezeman JJ,
PLoS ONE, 10, e0127058, 2015
Enhancing oncolytic therapy: IncuCyte™ real-time monitoring of viral replication in patient-derived glioblastoma stem-like cells identify co-treatments that augment viral infection and cause synergistic anti-tumor activity.
The number of IncuCyte™ references has surpassed 500! View the publications in each country and see which research institutions are using IncuCyte™ live-cell imaging.
If the bubble is on top of your cell culture media, ethanol vapor is a great way to rid yourself of them. Simply take an ethanol squeeze bottle, remove the internal straw and gently squeeze the bottle, while moving the tip across your plate, effectively blowing ethanol vapor across the surface of your media and ridding yourself of pesky top-side bubbles. We at Essen BioScience call these handy bottles “Debubblers”!
A: You must archive and delete scans to free up space to continue scanning. Note that once data is archived it cannot be re-analyzed again. To initiate archiving, select the Archives option located on the left side task list. Once selected, the “Create New Archive” table is active, displaying all vessels available for archiving. Users can search the entire Archiving Vessels table using the “Find” field or within individual columns.
Once the vessels of interest are sorted (e.g. by date or by project), Users may select vessels individually or use the “Select All” button located in the lower left-corner of the window. Select the “Create Archive” button in the lower right-corner of the window and you will be asked to specify the archive destination. Users have the option to select either “My Computer” or “Storage Attached to ZOOM”. Depending on how large the archive is, it could take hours, or even days. It’s best to archive in smaller chunks then a huge TB+ size at a time.
After archiving, you can delete those scans to free up more space. Select the Admin option on the left side task list, and then select the Delete tab. Once selected, the table is active displaying all scans available for deleting. Select the scans you previous archived for delete and click Delete.
Our New Lab Startup Program is a program designed to help you get your new lab up and running. The program connects you with exclusive discounts and resources such as a discount on your first IncuCyte™ system order.
To verify your eligibility, please visit our website and register.
Our IncuCyte™ Referral Program is a program that rewards you when someone you refer to us, purchases an IncuCyte™ system.
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