White Paper: Improving in-vitro Models for Alzheimer’s Disease
Overview
Alzheimer’s disease (AD) is a progressive, chronic neurodegenerative disease characterized by brain atrophy, β amyloid plaque deposition, tau protein neurofibrillary tangles (NFTs) and loss of neurons and synapses.
Neuroscience traditionally depends on the use of tumor cell lines, primary animal, or post-mortem human tissue to study AD. All these approaches are limited in that they do not fully represent the complexity and plasticity of the human brain, limiting the translational value of the models.
Studies have shown that 2D or 3D cell culture approaches address this limitation by providing more biologically relevant insights. In addition to better in-vitro models, improved assays and technologies that can capture the data that these models can generate is vital to accelerate AD therapeutic development.
- Document type: White Paper
- Page count: 10
- Read time: 10 minutes
Key Takeaways
Download this white paper to:
- Learn how live cell analysis of 3D cellular models provides a better understanding of the mechanisms of AD by addressing the limitations of traditional methods
- Explore the contrasting roles of microglia as key players in late onset AD
- Understand the advantages and limitations of current biology technologies used in AD research
Differential neurite formation from AD patient-derived iPSCs
