Alzheimer’s disease (AD) is a progressive, chronic neurodegenerative disease characterized by brain atrophy, β amyloid plaque deposition, tau protein neurofibrillary tangles (NFTs) and loss of neurons and synapses.
Neuroscience traditionally depends on the use of tumor cell lines or primary animal or postmortem human tissue to study AD. All of these approaches are limited in that they do not fully represent the complexity and plasticity of the human brain, limiting the translational value of the models.
Studies have shown that 2D or 3D cell culture approaches address these limitation by providing more biologically relevant insights. In addition to better in-vitro models improved assays and technologies that can capture the data that these models can generate is vital to accelerate AD therapeutic development.
Download this white paper to learn how live cell analysis of 2D and 3D models provides a better understanding of the mechanism of AD by addressing the limitations of traditional methods.