Our understanding of cancer cell biology has progressed enormously since Hanahan and Weinberg published their landmark paper describing six hallmarks of cancer in 2000. Since this time, breakthroughs in areas such as immune modulation and the tumor microenvironment have led to these hallmarks being revised and updated.
This constantly evolving picture of tumor biology is helping to shed new light on the behavior of many cancers, as well as providing new pharmacological targets and treatment strategies. Much of this progress has been driven by technological advances, enabling previously unachievable studies to be performed. The last decade in particular has seen huge strides made in the field of in vitro translational models and in vitro live-cell assays, using both traditional 2D techniques and advanced 3D cell culture models systems.
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