IncuCyte Models

INCUCYTE™

Our original model changed everything. It was the first – and still is the only – fully automated, phase-contrast, compact microscope that can be placed inside a standard tissue culture incubator enabling a range of uses including cell culture QC, cell-based assay optimization and several long-term, non-labeled, kinetic assay readouts.

INCUCYTE HD

The primary distinction between this and our base model is the High Definition (HD) imaging mode. The IncuCyte HD is suitable for the same broad range of applications, but is insensitive to imaging aberrations caused by the fluid meniscus found in 96- and 384-well plates. HD imaging greatly improves phase-contrast imaging in microplates. We have also used the HD image quality to enhance our quantitative readout of assays such as our CellPlayer^TM Migration assay.

INCUCYTE FLR

Though it retains all the phase contrast features of the base model and IncuCyte HD, this version is also a fluorescence microscope, enabling the detection of cells expressing GFP, as well as fluorescent dyes or tagged antibodies. We have used the IncuCyte FLR to build next-generation fluorescent assays for processes like angiogenesis, bringing a kinetic read-out to what have traditionally been end-point assays. We also provide a calibration kit which allows researchers to quantify and compare fluorescent values from different experiments run at different times.

INCUCYTE EX

Unlike our other IncuCyte models, the IncuCyte EX is designed to function outside the incubator, providing integrated image acquisition, analysis and archival to automated cell culture platforms. This integrated approach allows automated cell culture systems to make better decisions when splitting cells and provides users of these systems accessibility to archived images and growth curves via the IncuCyte user interface. Like other IncuCyte models, users have the ability to define where the images are taken, however the timing of acquisition is controlled by the robotics platform using a versatile command language interface.